Brand name: methotrexate
Generic name: MTX, Emthexate, Methoblastin, amethopterin, Rheumatrex

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Cutaneous lesions partially remitted following infliximab discontinuation and methotrexate treatment. It works like folic acid in the body, which helps to reduce the action and toxic effects of folic acid antagonists (eg, methotrexate). He was treated for RA with infliximab (3 mg/kg) for 3 years, as well as methotrexate (20 mg/week), and corticosteroids. Methotrexate, especially at higher doses or with prolonged treatment, has been associated with hepatotoxicity including acute hepatitis, chronic fibrosis, necrosis, cirrhosis, and liver enzyme elevations. Taking methotrexate and alcohol together may increase the risk of liver injury. Antibodies developed in 12% of patients on adalimumab monotherapy and in 1% of patients on concurrent methotrexate. MANAGEMENT: The use of methotrexate in combination with other potentially hepatotoxic agents (e. Interstitial pneumonitis has been reported in a limited number of patients receiving infliximab concomitantly with a stable dosage of methotrexate. His only other medications were amlodipine (5 mg per day) and methotrexate (15 mg per week). In patients receiving concomitant methotrexate, the incidence was 6% compared to 26% with Humira monotherapy. This indicates that NSAIDs may enhance the toxicity of methotrexate.

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